Summary of Effects of APPA on Neutrophils

AKLRD, in collaboration with the University of Liverpool, were accepted for a presentation at the 2016 OARSI (Osteoarthritis Research Society International) Congress Summary of Effects of APPA on Human Neutrophils Function APPA is a synergistic combination of 2 synthetic anti-inflammatory molecules. APPA has shown efficacy in several animal models of osteoarthritis, decreasing pain and meniscal […]

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APPA has completed required preclinical studies

We believe APPA is now ready to apply for regulatory approval to start formal human trials now that required preclinical toxicology studies have been completed. There is a considerable body of evidence behind the efficacy, safety, tolerability and mode of action of APPA. Consistent with data in the public domain, the studies undertaken indicate that […]

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New Family Link to Osteoarthritis

Brothers and sisters of osteoarthritis patients are twice as likely to develop the condition themselves, according to researchers in the East Midlands. The study, carried out at Nottingham’s City Hospital, also discovered that men were more likely to inherit the disease than women. Osteoarthritis is a painful condition causing inflammation and loss of cartilage, most […]

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Paracetamol ‘useless’ in treating osteoarthritis pain

“Paracetamol is next to useless at alleviating arthritic pain,” The Times reports. A comprehensive review of existing data suggests paracetamol should not be used in cases of osteoarthritis as there are far more effective treatments available. Osteoarthritis is now the leading cause of joint pain and stiffness in older people. The review showed that paracetamol, […]

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BMJ: Painkillers linked to increased risk of heart failure

Common painkillers such as ibuprofen used by millions of people in the UK are linked to an increased risk of heart failure, experts have said. Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) could increase the risk of being admitted to hospital. Previous studies have linked the drugs to abnormal heart rhythm – which can cause heart failure […]

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Is there evidence that glucosamine improves things?

In collaboration with Prof Phil Conaghan of the University of Leeds, a world expert on joint pain, ‘Trust Me, I’m a Doctor’ recruited 80 people with painful knees. Phil and his team assessed their joints and asked them to rate their pain levels, and then 40 of them were given a “supplement pill” to take […]

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