Completion of Phase 2a Human Trial

AKL Research and Development (AKLRD) has recently completed a Phase 2a, 28-day 150 patient, trial of oral APPA in osteoarthritis (OA) of the knee

The data from this Phase 2a trial adds considerably to our understanding of APPA. It advances our ability to select the patients most likely to benefit from APPA. Key Findings from the trial:

  • APPA demonstrated significantly (p=0.02) greater pain relief than placebo in a predefined subgroup of patients with more severe disease
  • Subgroup is now the focus of further clinical development
  • Additional post hoc analyses also showed APPA treated patients with bilateral OA and higher baseline pain scores had significantly more pain relief than placebo

The data generated warrants a longer trial duration with multiple doses in a trial population of more severe OA, this also being the target commercial population